Nancy Gajee, PhD

Deidre Donaldson, PhD, ABPP, LABA, BCBA 

May Institute and the National Autism Center

Click here to download >>> Dr Deborah Levy's PPT on ASD and MH

Below are the three learning objectives of the presentation

1) In what ways are the genetic architecture of schizophrenia and autism similar?

2) Why is the genetic overlap between autism and schizophrenia unexpected?

3) What are some of the factors that seem to protect females from risk for autism?

Below are five references.

1.         The Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism 2017;8:21.

2.         Robinson EB, St Pourcain B, Anttila V, et al. Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nature 2016;48:552-555.

3.         Malhotra D, Sebat J. CNVs: Harbinger of a rare variant revolution in psychiatric genetics. Cell 2012;148:1223-1241.

4.         CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium, Marshall CR, Howrigan DP, et al. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects Nat Genet 2017;49:27-33.

5.         Sekar A, Bialas AR, de Rivera H, et al. Schizophrenia risk from complex variation of complement component 4. Nature 2016;530:177-183.